Mycobacterium tuberculosis Bacteremia as HIV-Infected Adults Confirms of Tuberculosis from Blood Samples of Evaluation of Xpert MTB/RIF for Detection
نویسندگان
چکیده
Published Ahead of Print 15 May 2013. 10.1128/JCM.00330-13. 2013, 51(7):2311. DOI: J. Clin. Microbiol. Heyderman, Elizabeth L. Corbett and David Alland Geoffrey A. Chipungu, Theresa J. Allain, Robert S. Howson, Derek J. Sloan, Aaron Mdolo, Catharina Boehme, Nicholas A. Feasey, Padmapriya P. Banada, William an Indicator of Poor Prognosis Mycobacterium tuberculosis Bacteremia as HIV-Infected Adults Confirms of Tuberculosis from Blood Samples of Evaluation of Xpert MTB/RIF for Detection
منابع مشابه
Evaluation of Xpert MTB/RIF for Detection of Tuberculosis from Blood Samples of HIV-Infected Adults Confirms Mycobacterium tuberculosis Bacteremia as an Indicator of Poor Prognosis
Tuberculosis (TB) remains a leading cause of death among HIV-infected adults, in part because of delayed diagnosis and therefore delayed initiation of treatment. Recently, the Gene-Xpert platform, a rapid, PCR-based diagnostic platform, has been validated for the diagnosis of TB with sputum. We have evaluated the Xpert MTB/RIF assay for the diagnosis of Mycobacterium tuberculosis bacteremia and...
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BACKGROUND A crucial impediment to global tuberculosis control is the lack of an accurate, rapid diagnostic test for detection of patients with active TB. A new, rapid diagnostic method, (Cepheid) Xpert MTB/RIF Assay, is an automated sample preparation and real-time PCR instrument, which was shown to have good potential as an alternative to current reference standard sputum microscopy and cultu...
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BACKGROUND The World Health Organization has endorsed the Xpert MTB/RIF assay for investigation of patients suspected of having tuberculosis (TB). However, its utility for routine TB screening and detection of rifampicin resistance among HIV-infected patients with advanced immunodeficiency enrolling in antiretroviral therapy (ART) services is unknown. METHODS AND FINDINGS Consecutive adult HI...
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BACKGROUND A major challenge faced by countries with a high burden of tuberculosis (TB) is early detection especially in individuals with paucibacillary disease which is common in HIV endemic settings. Remarkable efforts have been made globally to accelerate the development and expansion of new diagnostic technologies that allow better and earlier diagnosis of active tuberculosis particularly d...
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Studies investigating Xpert MTB/RIF diagnostic performance on cerebrospinal fluid (CSF) samples are lacking in resource-rich settings. Xpert MTB/RIF results for 740 CSF samples from 698 patients across England were retrospectively compared with the results of culture of the same and contemporary samples. The overall sensitivity was calculated at 55%.
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